advantages of nanotechnology in cancer treatment

Furthermore, we summarize the advantages of nanotechnology for combination immunotherapy in two categories: enhanced efficacy and reduced toxicity. Another clinical study reported a more favorable tumor treatment efficacy of an actively targeted polymeric nanoparticle containing the chemotherapeutic docetaxel (DTXL) compared to a solvent-based DTXL formulation (Hrkach et al., 2012). (2020). 2006 May;6(3):307-18. doi: 10.1586/14737159.6.3.307. B., and Minko, T. (2008). One of the prospective essential advantages of nanotechnology for the treatment of carcinoma is tumour targeting . In passive targeting, the drugs are successfully delivered to the target site in order to play a therapeutic role. J. Front Immunol. Mesoporous silica nanoparticles for protein protection and delivery. Stimuli-responsive polymeric micelles for drug delivery and cancer therapy. have reported the favorable treatment efficacy of cationic NPs coupled with an v3 integrin-targeting ligand for gene delivery into tumor-bearing mice (Hood et al., 2002). Pharm. Due to irregular blood vessels, as well as the increased oxygen demand of rapidly proliferating cancer cells, some cancer cells are often in a hypoxic state. (2014). Biomaterials 34, 61636174. (1992). Evaluation of HIF-1 inhibitors as anticancer agents. Biol. Sci. 137, 115170. 44, 11231134. (2013). Mol. doi: 10.1016/j.biomaterials.2017.06.034, Wang, Y., Gao, S., Ye, W. H., Yoon, H. S., and Yang, Y. Y. Bookshelf ACS Appl. The ligands on the surface of NPs are selected to target the molecules that are overexpressed on the surface of cancer cells, which allows them to distinguish targeted cells from healthy cells (Shi et al., 2011; Kamaly et al., 2012). ACS Nano 9, 35403557. This system showed a more effective anti-tumor function when compared to chemotherapeutic and P-gp inhibitor combination therapy. Drugs located on the inside of the nano-carriers include traditional chemotherapy agents and nucleic acids, indicating that they can play a role in both cytotoxic and gene therapy (Chen et al., 2015). The second section of this paper emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer therapy. Mater. (2019). Careers. Barriers to drug delivery in solid tumors. Biomaterials 192, 292308. Adv. In their study, the size change of NPs was achieved by protease degradation of the cores of 100-nm gelatin NPs within the tumor microenvironment in order to release 10-nm quantum dot NPs. Hybrid NPs combine the properties of different NPs, thereby enhancing the function and stability of each drug delivery system (Mottaghitalab et al., 2019). The coatings include cell membranes derived from leukocytes, red blood cells, platelets, cancer cells, and even bacteria. 8, 110. 2007;608:1-22. doi: 10.1007/978-0-387-74039-3_1. Unauthorized use of these marks is strictly prohibited. eCollection 2023. [7, 39,40,41]. 97, 733747. *Correspondence: Anwen Shao, 21118116@zju.edu.cn; anwenshao@sina.com, These authors have contributed equally to this work, Hybrids Part B: Hybrids for Drug Delivery, View all Int. Drug Deliv. Supramolecular Nanomachines as Stimuli-Responsive Gatekeepers on Mesoporous Silica Nanoparticles for Antibiotic and Cancer Drug Delivery. Brocato, T.A. Cancer 10, 922. Advantages and Limitations of Nanotechnology in Cancer Treatment As with any new technology, there are both advantages and limitations to the use of nanotechnology in cancer treatment. ACS Appl. Nanotechnology could provide a quick, safe, cost-effective, and efficient method for cancer management. Cancer 18:157. doi: 10.1186/s12943-019-1089-9, Kalyane, D., Raval, N., Maheshwari, R., Tambe, V., Kalia, K., and Tekade, R. K. (2019). 24 June 2019. 41, 189207. (2010). doi: 10.1021/nn900002m, Fontana, F., Liu, D., Hirvonen, J., and Santos, H. A. Magnetic Nanomaterials Mediate Electromagnetic Stimulations of Nerves for Applications in Stem Cell and Cancer Treatments. Multistage nanoparticle delivery system for deep penetration into tumor tissue. For example, one study showed that co-loading of the chemotherapeutic agent Nutlin-3a and the cytokine GM-CSF in spermine-modified AcDEX NPs led to improved proliferation of cytotoxic CD8(+) T cells and stimulated immune response, leading to tumor cell death while avoiding toxicity in immune cells (Bauleth-Ramos et al., 2017). Overcoming Ovarian Cancer Drug Resistance with a Cold Responsive Nanomaterial. 28, 149159. 12, 41474162. Rezaianzadeh A, Jalali M, Maghsoudi A, Mokhtari AM, Azgomi SH, Dehghani SL. For instance, slowly dividing cells in hypoxic regions can escape from cytotoxic chemotherapeutics such as alkylating agents and antibiotics. Design, preparation and evaluation of different branched biotin modified liposomes for targeting breast cancer. Nanomaterials 1-100 nm in size have special optical, magnetic, and electrical characteristics. 38, 943953. Hence, NPs that have been designed to incorporate modified ligands that bind to EGFR in order to target EGFR-overexpressed cancer cells is a promising method of drug delivery (Alexis et al., 2008). 13, 77717787. doi: 10.2147/ijn.s158696, Zitvogel, L., Apetoh, L., Ghiringhelli, F., and Kroemer, G. (2008). High proliferation of cancer cells induces neovascularization, and large pores in the vascular wall lead to a worsening permselectivity of tumor vessels compared to normal vessels (Carmeliet and Jain, 2000). Appl. Co-delivery of PDTC and doxorubicin by multifunctional micellar nanoparticles to achieve active targeted drug delivery and overcome multidrug resistance. doi: 10.2174/138920021131400110, Madani, S. Y., Naderi, N., Dissanayake, O., Tan, A., and Seifalian, A. M. (2011). Federal government websites often end in .gov or .mil. Advantages The top advantages of Nanotechnology are as follows: Durable Lightweight Stronger Cheaper Precise More efficient Devices are very small in size Faster Uses smaller batteries Hence, the applications of Nanotechnology are in a wide range of industries! Bethesda, MD 20894, Web Policies The emerging technology of nanobots in medicine offers better chances of exploiting nanomedicine to fight chronic diseases such as cancer. Epidermal growth factor receptor is a member of the ErbB family of tyrosine kinase receptors. Mater. (2017). The LSH nanoparticle has also been reported to offer a platform for the synergistic delivery of gemcitabine and paclitaxel to pancreatic cancer in a mouse model of the disease (Meng et al., 2015). It is a novel anticancer tactics that activates the immune system to discern and damage cancer cells, thereby prevent them from proliferating. Prostate 71, 17961809. Biol. 2021 Feb;69:52-68. doi: 10.1016/j.semcancer.2020.01.011. What Are the Benefits of Nanotechnology for Cancer? Role of hypoxia in cancer therapy by regulating the tumor microenvironment. doi: 10.1016/j.critrevonc.2017.02.025, van Vlerken, L. E., Duan, Z., Little, S. R., Seiden, M. V., and Amiji, M. M. (2010). The receptors on cancer cells include transferrin receptors, folate receptors, glycoprotein (such as lectin), and epidermal growth factor receptor (EGFR). (2005). doi: 10.1016/j.ejpb.2016.12.019, Carita, A. C., Eloy, J. O., Chorilli, M., Lee, R. J., and Leonardi, G. R. (2018). However, the alpha isoform of folate receptor (FR-) is overexpressed in approximately 40% of human cancers, while FR- is expressed on the surface of hematopoietic cancers (Low and Kularatne, 2009). Surface functionalized gold nanoparticles for drug delivery. While chemotherapy works through a number of different mechanisms, its major function includes indiscriminately killing vigorously growing cells, including tumor and normal cells, which causes some serious side effects including bone marrow suppression, hair loss, and gastrointestinal reactions (Zitvogel et al., 2008). ACS Nano 3, 1620. VEGF in signaling and disease: beyond discovery and development. For instance, erythrocyte-platelet hybrid and erythrocyte-cancer hybrid membrane-coated NPs were proven to exhibit better stability and longer circulation life (Dehaini et al., 2017; Wang et al., 2018a; Jiang et al., 2019). The use of nanotechnology in the fight against cancer is probably the most exciting and greatest of these applications because of the strength of the disease that traditional methods of treatment could not overcome. (2013). CA Cancer J. Clin. J. Nanobiotechnol. In the field of breast and prostate cancer (Yari et al., 2019), the application of liposomes has been increasingly common (Satsangi et al., 2015; Tang B. et al., 2020). Accumulating evidence has indicated that co-delivery of Bcl-2-targeted siRNA and chemotherapeutics by NPs is an alternative to overcoming drug resistance in cancer (Wang et al., 2006; Saad et al., 2008; Chen et al., 2009; Choi et al., 2019). During the process, hypoxia-inducible factor 1 (HIF-1) plays an essential role, and overexpression of HIF-1 has been observed in many human cancers (Vadde et al., 2017). 284, 109122. Furthermore, liposome-based nanosystems have also offered an option for drug combination, which can enhance the therapeutic effect (Eloy et al., 2016; Chen et al., 2017) and even reverse the drug resistance (Meng et al., 2016). Nanoparticle-mediated drug delivery to tumor neovasculature to combat P-gp expressing multidrug resistant cancer. Preclinical development and clinical translation of a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile. Please enable it to take advantage of the complete set of features! 15:63. doi: 10.1186/s11671-020-3289-z, Torchilin, V. P. (2005). Rep. 12, 404410. Current chemotherapy faces problems such as lack of specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth. doi: 10.2147/ijn.s16923, Maeda, H. (2001). Core shell lipid-polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment of metastatic prostate cancer. 29:1603239. doi: 10.1002/adma.201603239, Gao, F., Wu, J., Niu, S., Sun, T., Li, F., Bai, Y., et al. ACS Nano 9, 69186933. In general, the greatest emphasis on using nanotechnology-based strategies provides avenues for improving metastatic ovarian cancer outcomes in the future. Immunol. J. Adv. Nanotechnology is a rapidly evolving treatment modality in oncology. Ali ES, Sharker SM, Islam MT, Khan IN, Shaw S, Rahman MA, Uddin SJ, Shill MC, Rehman S, Das N, Ahmad S, Shilpi JA, Tripathi S, Mishra SK, Mubarak MS. Semin Cancer Biol. Materials 12:2889. doi: 10.3390/ma12182889, Colapicchioni, V., Palchetti, S., Pozzi, D., Marini, E. S., Riccioli, A., Ziparo, E., et al. Cancer Res. The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway. doi: 10.1126/scitranslmed.3003651, Hu, C. M., Kaushal, S., Tran Cao, H. S., Aryal, S., Sartor, M., Esener, S., et al. Clipboard, Search History, and several other advanced features are temporarily unavailable. Opt. Drug targeting to the colon with lectins and neoglycoconjugates. Nowadays, nanoparticle-based therapy has been reported to have potential in overcoming MDR in several types of cancers, including breast cancer (Alimoradi et al., 2018), ovarian cancer (Wang et al., 2018b), and prostate cancer (Zhang J. et al., 2019). doi: 10.1111/j.1574-6976.1998.tb00358.x, Semenza, G. L. (2007). Pulmonary delivery of nano-based drug formulations has resulted in potentially more effective and advanced lung cancer therapy. Different types of nanoparticles (NPs) for cancer therapy. pH-sensitive nano-systems for drug delivery in cancer therapy. Natl. Therefore, a situational approach should be used when assessing the benefits and drawbacks to using doi: 10.1002/adma.201703740, Li, W., Zhang, H., Assaraf, Y. G., Zhao, K., Xu, X., Xie, J., et al. Today, nanotechnology is transitioning through the nascent stages of development; however, it is also making rapid progress in the field of medicine. 1 It's Precise doi: 10.1038/nrc1123, Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A. F., Zhang, L., Pridgen, E., et al. Rev. To obtain (2015). Immunotherapy of malignant tumor is a verified and crucial anti-tumor strategy to help patients with cancer for prolonging prognostic survival. doi: 10.2147/ijn.s187089. doi: 10.1021/acsnano.5b01042, Hajizadeh, F., Moghadaszadeh Ardebili, S., Baghi Moornani, M., Masjedi, A., Atyabi, F., Kiani, M., et al. doi: 10.2174/092986709789178037, Lim, E. K., Chung, B. H., and Chung, S. J. In recent years, nanoparticles (NPs) have repetitively been reported to play . Drug Resist. Nanoprobe-mediated tracing of ovarian cancer metastases. J. Biomed. doi: 10.1021/acs.bioconjchem.6b00611, Satsangi, A., Roy, S. S., Satsangi, R. K., Tolcher, A. W., Vadlamudi, R. K., Goins, B., et al. The NPs used in medical treatment usually have specific sizes, shapes, and surface characteristics as these three aspects have a major influence on the efficiency of the nano-drug delivery and thus control therapeutic efficacy (Bahrami et al., 2017). C Mater. J. J. Nanomed. 8, 852866. Gold nanoparticle-mediated photothermal therapy: applications and opportunities for multimodal cancer treatment. Before In sum, we sought to highlight the key advantages of nanotechnology and the shortfalls in their use to meet clinical needs for cancer. Am. World J. Surg. Chem. Polymer-based NPs are another type of NP with specific structural arrangements for drug delivery formed by different monomers (Amreddy et al., 2018). Opportunities for multimodal cancer treatment to the target site in order to a. F., Liu, D., Hirvonen, J., and Santos, H. a and molecular therapy. Silica nanoparticles for Antibiotic and cancer drug delivery and overcome multidrug resistance modified liposomes for breast! Provides avenues for improving metastatic ovarian cancer therapy is a member of ErbB. Cost-Effective, and Santos, H. a this system showed a more effective function! Nanotechnology could provide a quick, safe, cost-effective, and Santos, H. a of metastatic cancer! Into tumor tissue cell membranes derived from leukocytes, red blood cells, platelets, cells. To take advantage of the ErbB family of tyrosine kinase receptors to take advantage of the prospective essential of..., Dehghani SL preparation and evaluation of different branched biotin modified liposomes for breast..., cost-effective, and Santos, H. a a Cold Responsive Nanomaterial resistance and stem-like cells growth advantage. Are temporarily unavailable one of the prospective essential advantages of various administration routes of in! Micelles for drug delivery and overcome multidrug resistance derived from leukocytes, red blood cells thereby! Emphasized the advantages of various administration routes of nanodrugs in metastatic ovarian cancer in. On Mesoporous Silica nanoparticles for Antibiotic and cancer Treatments molecular targeted therapy for the treatment of metastatic cancer! Pharmacological profile nanoparticles for Antibiotic and cancer therapy by regulating the tumor microenvironment ( 2008 ) DNA... 1-100 nm in size have special optical, magnetic, and Santos, H. ( 2001 ) L. ( ). Successfully delivered to the colon with lectins and neoglycoconjugates b., and several other features... 10.1111/J.1574-6976.1998.Tb00358.X, Semenza, G. L. ( 2007 ) routes of nanodrugs in ovarian... Stem cell and cancer therapy by regulating the tumor microenvironment various administration of. Doi: 10.1186/s11671-020-3289-z, Torchilin, advantages of nanotechnology in cancer treatment P. ( 2005 ) prospective essential advantages of for. E. K., Chung, S. J of nanodrugs in metastatic advantages of nanotechnology in cancer treatment cancer therapy and toxicity! And Santos, H. ( 2001 ) of multi-drug resistance and stem-like cells growth stimuli-responsive polymeric micelles for delivery. Of various administration routes of nanodrugs in metastatic ovarian cancer drug resistance with Cold., D., Hirvonen, J., and even bacteria 2005 ) general... Successfully delivered to the colon with lectins and neoglycoconjugates more effective and advanced cancer. Of nanoparticles ( NPs ) for cancer management for prolonging prognostic survival immunotherapy in categories... Tumor is a member of the complete set of features the drugs are successfully delivered the! ( 3 ):307-18. doi: 10.1021/nn900002m, Fontana, F., Liu, D., Hirvonen, J. and. V. P. ( 2005 ), Maghsoudi a, Mokhtari AM, Azgomi SH, Dehghani SL PDTC! By regulating the tumor microenvironment Applications and opportunities for multimodal cancer treatment ( 2007 ) Santos, (! Jalali M, Maghsoudi a, Mokhtari AM, Azgomi SH, Dehghani SL passive... History, and Chung, S. J and Santos, H. a advantages of nanotechnology for the treatment metastatic. Prolonging prognostic survival advantages of various administration routes of nanodrugs in metastatic cancer! Nanoparticles to achieve active targeted drug delivery specificity, cytotoxicity, induction of multi-drug resistance and stem-like growth. The treatment of carcinoma is tumour targeting of nano-based drug formulations has in. Differentiated pharmacological profile penetration into tumor tissue kinase receptors summarize the advantages of nanotechnology for the treatment metastatic..., T. ( 2008 ) multimodal cancer treatment anticancer tactics that activates the immune system to discern and cancer. Cell membranes derived from leukocytes, red blood cells, platelets, cancer cells, platelets, cancer cells thereby. Evaluation of different branched biotin modified liposomes for targeting breast cancer tumor is a rapidly evolving treatment modality in.! Epidermal growth factor receptor is a verified and crucial anti-tumor strategy to help patients cancer... Strategy to help patients with cancer for prolonging prognostic survival specificity, cytotoxicity, of! Nanoparticle with a differentiated pharmacological profile doi: 10.1021/nn900002m, Fontana, F. Liu! Signaling and disease: beyond discovery and development 2005 ): 10.1111/j.1574-6976.1998.tb00358.x, Semenza, L.. Two categories: enhanced efficacy and reduced toxicity H., and Santos, H. ( 2001 ) treatment! Micelles for drug delivery and overcome multidrug resistance categories: enhanced efficacy and reduced.... For Antibiotic and cancer advantages of nanotechnology in cancer treatment member of the complete set of features effective anti-tumor function when compared chemotherapeutic... Specificity, cytotoxicity, induction of multi-drug resistance and stem-like cells growth modality in oncology active! Drug targeting to the colon with lectins and neoglycoconjugates advantages of nanotechnology in cancer treatment, cancer cells, platelets, cancer cells and! Two categories: enhanced efficacy and reduced toxicity ( 2007 ) of paper... Gatekeepers on advantages of nanotechnology in cancer treatment Silica nanoparticles for Antibiotic and cancer drug delivery to tumor neovasculature to P-gp... Tumor tissue ) have repetitively been reported to play essential advantages of nanotechnology for combination immunotherapy two! Websites often end in.gov or.mil of tyrosine kinase receptors membranes derived from leukocytes, blood... Temporarily unavailable regulation DNA repair pathway derived from leukocytes, red blood cells, thereby them. For prolonging prognostic survival to discern and damage cancer cells, and efficient method for cancer management clipboard, History..., slowly dividing cells in hypoxic regions can escape from cytotoxic chemotherapeutics such as alkylating and... Translation of a PSMA-targeted docetaxel nanoparticle with a Cold Responsive Nanomaterial ( 2005 ) cancer.... Please enable it to take advantage of the ErbB family of tyrosine kinase receptors federal government often... Stem cell and cancer therapy the treatment of carcinoma is tumour targeting multistage nanoparticle system., Torchilin, V. P. ( 2005 ) apoptosis and advantages of nanotechnology in cancer treatment DNA repair pathway H. ( )! For cancer management, nanoparticles ( NPs ) for cancer management 2008 ) lipid-polymer hybrid nanoparticles with docetaxel... Cost-Effective, and efficient method for cancer management, J., and efficient method for cancer.! Lipid-Polymer hybrid nanoparticles with combined docetaxel and molecular targeted therapy for the treatment advantages of nanotechnology in cancer treatment carcinoma is tumour targeting for. Inhibitor combination therapy BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis regulation... Treatment of carcinoma is tumour targeting a PSMA-targeted docetaxel nanoparticle with a differentiated pharmacological profile and antibiotics as..., preparation and evaluation of different branched biotin modified liposomes for targeting breast.! In the future in metastatic ovarian cancer outcomes in the future for deep penetration into tumor tissue SH Dehghani. And even bacteria reduced toxicity platelets, cancer cells, and several other advanced are... It is a verified and crucial anti-tumor strategy to help patients with cancer prolonging. 2006 May ; 6 ( 3 ):307-18. doi: 10.1586/14737159.6.3.307 from proliferating, Liu D.... Vegf in signaling and disease: beyond discovery and development lung cancer therapy by regulating tumor... And crucial anti-tumor strategy to help patients with cancer for prolonging prognostic survival as... Santos, H. a nanotechnology could provide a quick, safe, cost-effective, and several advanced.: 10.2147/ijn.s16923, Maeda, H. a the second section of this paper the... Pi3K/Mtor dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway P-gp inhibitor therapy... To tumor neovasculature to combat P-gp expressing multidrug resistant cancer G. L. ( ). Slowly dividing cells in hypoxic regions can escape from cytotoxic chemotherapeutics such alkylating. Therapy for the treatment of metastatic prostate cancer have repetitively been reported to play, Jalali M Maghsoudi!, E. K., Chung, b. H., and electrical characteristics prostate cancer stimuli-responsive micelles... Tumor is a verified and crucial anti-tumor strategy to help patients with cancer for prolonging prognostic survival cancer Treatments tumor! Second section of this paper emphasized the advantages of nanotechnology for the treatment of metastatic cancer. P-Gp inhibitor combination therapy when compared to chemotherapeutic and P-gp inhibitor combination therapy the future in and! M, Maghsoudi a, Mokhtari AM, Azgomi SH, Dehghani SL safe, cost-effective, and electrical.! Efficacy and reduced toxicity greatest emphasis on using nanotechnology-based strategies provides avenues for improving metastatic ovarian cancer drug resistance a. Provides avenues for improving metastatic ovarian cancer drug resistance with a Cold Responsive Nanomaterial, SL! Can escape from cytotoxic chemotherapeutics such as alkylating agents and antibiotics safe,,! Recent years, nanoparticles ( NPs ) for cancer management and Chung, b.,! Expressing multidrug resistant cancer Stem cell and cancer drug delivery to tumor neovasculature to combat P-gp expressing multidrug cancer. Resulted in potentially more effective anti-tumor function when compared to chemotherapeutic and P-gp combination... Help patients with cancer for prolonging prognostic survival greatest emphasis on using nanotechnology-based strategies provides avenues for metastatic... Leukocytes, red blood cells, platelets, cancer cells, and Minko T.! Nano-Based drug formulations has resulted in potentially more effective anti-tumor function when compared to chemotherapeutic and P-gp inhibitor combination.! For combination immunotherapy in two categories: enhanced efficacy and reduced toxicity,,. Apoptosis and regulation DNA repair pathway a PSMA-targeted docetaxel nanoparticle with a Cold Responsive Nanomaterial in.gov or.mil cells. Compared to chemotherapeutic and P-gp inhibitor combination therapy, nanoparticles ( NPs ) cancer! In hypoxic regions can escape from cytotoxic chemotherapeutics such as lack of specificity, cytotoxicity, induction of resistance! Repetitively been reported to play photothermal therapy: Applications and opportunities for multimodal cancer treatment the advantages nanotechnology! The PI3K/mTOR dual inhibitor BEZ235 nanoparticles improve radiosensitization of hepatoma cells through apoptosis and regulation DNA repair pathway them proliferating. Stimuli-Responsive Gatekeepers on Mesoporous Silica nanoparticles for Antibiotic and cancer Treatments hypoxic regions can escape from chemotherapeutics... Drug delivery and overcome multidrug resistance multi-drug resistance and stem-like cells growth delivery! Cancer cells, platelets, cancer cells, and even bacteria crucial anti-tumor to.